The magazine features articles, reviews of hardware and software, editorial content and classified advertising. It is geared toward more advanced users than its sister publication, SmartComputing. Regular guest writers used to include Chris Pirillo. CPU Magazine differs from most other computing magazines in that it focuses more on the latest hardware rather than software or gaming. The advertisements are, however, strongly aimed at gamers and users of multimedia software.
Many of their articles are actually paid advertisements, which they call "custom editorials."